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苏志国课题组

Su Zhiguo ?Ph. D.

课题组长、研究员

英国曼彻斯特大学博士学位(1985年)

Email: zgsu@ipe.ac.cn

研究领域

蛋白质药物的分子修饰

血液代用品

蛋白质折叠复性

超大生物分子的纯化及结构稳定

发表的主要论文(近5年)

[1] Xiaoyuan Ji, Zhiguo Su, Ping Wang, Guanghui Ma, Songpin Zhang. ? Tethering of nicotinamide adenine dinucleotide inside hollow nanofibers ? for high-yield synthesis of methanol from carbon dioxide catalyzed by ? coencapsulated multienzymes. ACS Nano, 2015, 9 (4): 4600-4610. (IF ? 14.412)
[2] Hong Wu, Chunyong Tian, Yufei Zhang, Chen Yang, ? Songping Zhang, Zhongyi Jiang. Stereoselective assembly of amino ? acid-based metal-biomolecule nanofibers. Chemical Communications, 2015, ? 2015, 51: 6329-6332. (IF 6.779)
[3] Hong Wu, Chunyong Tian, Yufei ? Zhang, Jiafu Shi, Songpin Zhang. Mask-like symmetrical microclusters ? through a diffusion-limited assembly approach. Chemistry-A European ? Journal, 2015, 21(28): 10185-10190. (IF 5.635)
[4] Yanli Yang, ? Mengran Yu, Songpin Zhang, Guanghui Ma, Zhiguo Su. Adsorption of ? virus-like particles on ion exchange surface: conformational changes at ? different pH detected by dual polarization interferometry. Journal of ? Chromatography A, 2015, 1408: 161-168. (IF 4.298)
[5] Mengran Yu, ? Songpin Zhang, Yan Zhang, Yanli Yang, Guanghui Ma, Zhiguo Su. ? Microcalorimetric study of adsorption and disassembling of virus-like ? particles on anion exchange chromatography media. Journal of ? Chromatography A, 2015, 1388:195-206. (IF 4.298)
[6] Liting Zhang, ? Xiaodan Cao, Lu Wang, Xueyan Zhao, Songpin Zhang, Ping Wang. Printed ? microwells with highly stable thin-film enzyme coatings for ? point-of-care multiplex bioassay of blood samples. Analyst, 2015, ? 140:4105-4113. (IF 4.14)
[7] Yanli Yang, Hao Li, Zhengjun Li, Yan ? Zhang, Songpin Zhang, Yi Chen, Mengran Yu, Guanghui Ma, Zhiguo Su. ? Size-exclusion HPLC provides a simple, rapid, and versatile alternative ? method for quality control of vaccines by characterizing the assembly of ? antigens. Vaccine, 2015, 33(9): 1143-1150. (IF 3.338)
[8] Yi ? Chen, Yan Zhang, Can Quan, Jian Luo, Yanli Yang, Mengran Yu, Yingjun ? Kong, Guanghui Ma, Zhiguo Su. Aggregation and antigenicity of virus like ? particle in salt solution-A case study with hepatitis B surface ? antigen. Vaccine, 2015, 33(35): 4300-4306. (IF 3.338)
[9] Dawei ? Zhao, Yongdong Liu, Guifeng Zhang, Chun Zhang, Xiunan Li, Qingqing Wang, ? Hong Shi, Zhiguo Su. Interaction of arginine with protein during ? refolding process probed by amide H/D exchange mass spectrometry and ? isothermal titration calorimetry. Biochim Biophys Acta, 2015, ? 1854:39-45. (IF 3.127)
[10] Xiaoyu Yan, Yanjun Jiang, Songpin ? Zhang, Jing Gao, Yufei Zhang. Dual-functional oph-immobilized polyamide ? nanofibrous membrane for effective organophosphorus toxic agents ? protection. Biochemical Engineering Journal, 2015, 98: 47-55. (IF 2.989)
[11] ? Lijing Sun, Zhidong Xiong, Weiqing Zhou, Ruihua Liu, Xingran Yan, Juan ? Li, Wenqi An,Yuan Guoqiang, Guanghui Ma, Zhiguo Su. Novel konjac ? glucomannan microcarriers for anchorage-dependent animal cell culture. ? Biochemical Engineering Journal, 2015, 96: 46-54. (IF 2.989)
[12] ? Yan Zhang, Jian Luo, Songpin Zhang, Qian Bai, Zenglan Li, Qiang Li, ? Yongdong Liu, Guifeng Zhang, Guanghui Ma, Zhiguo Su. Selection of ? downstream steps by analysis of protein surface property: a case study ? for recombinant human lactoferrin purification from transgenic milk. ? Process Biochemistry, 2015, 50: 1441-1448. (IF 2.909)
[13] Chun ? Zhang, Yongdong Liu, Cui Feng, Qi Wang, Hong Shi, Dawei Zhao, Rong Yu, ? Zhiguo Su. Loss of PEG chain in routine SDS-PAGE analysis of ? PEG-maleimide modified protein. Electrophoresis, 2015, 36 (2): 371-374. ? (IF 2.723)
[14] Manfeng Deng, He Zhao, Songping Zhang, Chunyong ? Tian, Di Zhang, Penghui Du, Chenming Liu, Hongbin Cao, Heping Li, Highly ? catalytic activity of immobilized laccase on core-shell magnetic ? nanoparticles by dopamine self-polymerization, Journal of Molecular ? Catalysis B: Enzymatic, 2015, 112: 15-24. (IF 2.622)
[15] Shida ? Miao, Kai Liu, Ping Wang, Zhiguo Su, Songping Zhang. Preparation and ? characterization of epoxidized soybean oil-based paper composite as ? potential water-resistant materials. Journal of Applied Polymer Science, ? 2015, 132(10): 41575-41583. (IF 1.662)
[16] Hao Li, Yanli Yang, ? Yan Zhang, Songping Zhang, Qizu Zhao, Yuanyuan Zhu, Xingqi Zou, Mengran ? Yu, Guanghui Ma, Zhiguo Su. A hydrophobic interaction chromatography ? strategy for purification of inactivated foot and mouth disease virus. ? Protein Expression Purification, 2015. 113: 23-29. (IF 1.617)
[17] ? Xiunan Li, Yaqiong Chen, Chao Zhao, Dawei Wang, Xiaojun Zhao, Lan Shi, ? Guanghui Ma, Zhiguo Su. Pore size analysis from low field NMR spin-spin ? relaxation measurements of porous microspheres. Journal of Porous ? Materials, 2015, 22(1): 11-13. (IF 1.343)
[18] Qingqing Wang, Tao ? Hu, Lijing Sun, Shaoyang Jia, Dawei Zhao, Jiaxin Liu, Guanghui Ma, ? Zhiguo Su. CO binding improves the structural, functional, physical and ? anti-oxidation properties of the PEGylated hemoglobin. Artificial Cells ? Nanomedicine and Biotechnology, 2015, 43(1): 18-25. (IF 1.015)
[19] ? Kai Liu, Songping Zhang, Zhiguo Su, Guanghui Ma. Preparation and ? characterization of castor oil-based cationic waterborne polyurethane. ? Advanced Materials Research, 2015, 1090: 3-7.
[20] 冯翠,王祺,张纯,秦培勇,郑秀玉,王健,刘永东,苏志国,PEG 定点修饰重组人睫状神经营养因子及其生物活性评价,中国生物工程杂志,2015, 35 (5): 15-21。
[21] 李小连,王自强,王云山,董晓芳,张利平,苏志国,醋糟酶解液的制备及发酵生产枯草芽孢杆菌TS-02,过程工程学报,2015, 2: 86-92。
[22]Xiaoyuan ? Ji, Zhiguo Su, Ping Wang, Guanghui Ma, Songping Zhang. Polyelectrolyte ? doped hollow nanofibers for positional assembly of bi-enzyme system for ? cascade reaction at O/W interface. ACS Catalysis. 2014, 4(12): 4548?455
[23]Shida ? Miao, Ping Wang, Zhiguo Su, Songping Zhang. Vegetable oil-based ? polymers as future polymeric biomaterials. Acta Biomaterialia. 2014, ? 10(4):1692–1704 (Invited review).?
[24]Xiaoyuan Ji, Ping Wang, ? Zhiguo Su, Guanghui Ma, Songping Zhang. Enabling multienzyme ? biocatalysis using coaxial-electrospun hollow nanofibers: redesign of ? artificial cells. J Material Chemistry B. 2014, 2: 181-190?
[25]Xiaoyuan ? Ji, Zhiguo Su, Ping Wang, Guanghui Ma, Songping Zhang.Ready-to-use hollow nanofibers membrane-based glucose testing strips. Analyst. 2014, ? 139(24): 6467-6473
[26]Zhan Zhou, Jing Zhang, Lijing Sun, Guanghui ? Ma, Zhiguo Su. Comparison of site-specific pegylations on n-terminal of ? interferon beta-1b: selectivity, efficiency, and in vivo/vitro ? activity. Bioconjugate Chemistry, 2014, 25: 138-146
[27]Mengran ? Yu, Yan Li, Songping Zhang, Xiunan Li, Yanli Yang, Yi Chen, Guanghui Ma, ? Zhiguo Su. Improving stability of virus-like particles by ion-exchange ? chromatographic supports with large pore size: advantages of gigaporous ? media beyond enhanced binding capacity. J Chromatography A. 2014, ? 1331:69-79.
[28]Jiandong Cui, Lili Cui, Songping Zhang, Yufei ? Zhang, Zhiguo Su, Guanghui Ma. Hybrid magnetic cross-linked enzyme ? aggregates of phenylalanine ammonia lyase from Rhodotorula glutinis. ? Plos One. 2014, 9(5): e97221?
[29]Zhidong Xiong, Weiqing Zhou, ? Lijing Sun, Xiunan Li, Dawei Zhao, Yi Chen, Juan Li, Guanghui Ma, Zhiguo ? Su. Konjac glucomannan microspheres for low-cost desalting of protein ? solution. Carbohydrate Polymers. 2014, 111: 56-62
[30]Qingqing ? Wang, Lijing Sun, Shaoyang Ji, Dawei Zhao, Jiaxin Liu, Zhiguo Su, Tao ? Hu. Reversible protection of Cys-93(?) by PEG alters the structural and ? functional properties of the PEGylated hemoglobin. Biochimica Biophysica ? Acta. 2014, 1844(7):1201-1207
[31]Fei Peng, Yongdong Liu, Xiunan ? Li, Lijing Sun, Dawei Zhao, Qingqing Wang, Guanghui Ma, Zhiguo Su. ? PEGylation of G-CSF in organic solvent markedly increases the efficacy ? and reactivity through protein unfolding, hydrolysis inhibition and ? solvent effect. J Biotechnology. 2014, 170: 42-49
[32]Bohm K, ? Lijing Sun, Thakor D, Wirth M. Caveolin-1 limits human influenza A virus ? (H1N1) propagation in mouse embryo-derived fibroblasts. Virology. 2014, ? 462-463C:241-253
[33]Dawei Zhao, Yongdong Liu, Yinjue Wang, ? Xiunan Li, Qingqing Wang, Zhiguo Su. Membrane combined with hydrophilic ? macromolecules enhancesprotein refolding at high concentration. Process ? Biochemistry. 2014, 49: 1129-1134
[34]Ziqiang Wang, Yunshan Wang. ? Hong Shi, Zhiguo Su. Improvement of the production efficiency of ? L-(+)-tartaric acid by heterogeneous whole-cell bioconversion. Applied ? Biochemistry & Biotechnology. 2014, 172: 3989-4001
[35]Panpan ? Luan, Yanjun Jiang, Songping Zhang, Jing Gao, Zhiguo Su, Guanghui Ma, ? Yufei Zhang. Chitosan-mediated formation of biomimetic silica ? nanoparticles: An effective method for manganese peroxidase ? immobilization and stabilization. J Bioscience Bioengineering. 2014, ? 118(5): 575-582?
[36]Chun Zhang, Yongdong Liu, Dawei Zhao, Xiunan ? Li, Rong Yu, Zhiguo Su. Facile purification of Escherichia coli ? expressed tag-free recombinant human tumor necrosis factor alpha from ? supernatant. Protein Expression Purification. 2014, 95: 195-203
[37]Jiandong ? Cui, Yan Li, Xiaoyan Ji, Bian HJ, Yufei Zhang, Zhiguo Su, Guanghui Ma, ? Songping Zhang. Bio-sequestration of CO2 using carbonic anhydrase in ? situ encapsulated inside electrospun hollow fibers. Chemical J Chinese ? University, 2014, 35(9): 1999-2006?
[38]Feng Xiaoyi, Gao Fei, Qin ? Peiyong, Ma Guanghui, Su Zhiguo, Ge Jia, Wang Ping*, Zhang Songping*. ? Real time monitoring of on-chip coenzyme regeneration with SPR and DPI. ? Analytical Chemistry. 2013, 85(4): 2370-2376.?
[39]Ku Zhiqiang, Ye ? Xiaohua, Huang Xulin, Cai Yicun, Liu Qingwei, Li Yan, Su Zhiguo, Huang ? Zhong*. Neutralizing antibodies induced by recombinant virus-like ? particles of enterovirus 71 genotype C4 inhibit infection at pre- and ? post-attachment steps. PLoS ONE. 2013, 8(2): 7601.?
[40]Wang Ziqiang, Wang Yunshan, Su Zhiguo*. Purification ? and characterization of a cis-epoxysuccinic acid hydrolase from ? Nocardia tartaricans CAS-52, and expression in Escherichia coli. Applied ? Microbiology Biotechnology. 2013, 97: 2433-2441.?
[41]Zheng ? Muqing, Su Zhiguo, Ji Xiaoyuan, Ma Guanghui, Wang Ping*, Zhang ? Songping*. Magnetic field intensified bi-enzyme system with in situ ? cofactor regeneration supported by magnetic nanoparticles. Journal of ? Biotechnology. 2013, 168: 212-217.?
[42]Zheng Yingfu, Zhang ? Songping, Miao Shida, Su Zhiguo*, Wang Ping*. Temperature sensitivity of ? cellulase adsorption on lignin and its impact on enzymatic hydrolysis ? of lignocellulosic biomass. Journal of Biotechnology. 2013, 166: ? 135-143.?
[43]Luo Jian, Zhou Weiqing, Su Zhiguo, Ma Guanghui, Gu ? Tingyue*. Comparison of fully-porous beads and cored beads in size ? exclusion chromatography for protein purification. Chemical Engineering ? Science. 2013, 102: 99-105.?
[44]Miao Shida,Callow Nicholas, Zhang ? Songping, Su Zhiguo, Wang Ping*, Liu Yongyan. Enzymatic synthesis of ? oleic acid-based epoxy monomer for the production of value added ? polymers. Biotechnology Letters. 2013, 35(6): 887-890.?
[45]Miao ? Shida,Callow Nicholas, Wang Ping, Liu Youyan, Su Zhiguo, Zhang ? Songping*. Soybean oil-based polyurethane networks: shape-memory effects ? and surface morphologies. Journal of the American Oil Chemists' ? Society. 2013, 90: 1415-1421.?
[46]Zhao Lan, Liu Yongdong, Wang ? Yinjue, Huang Yongdong, Li Xiunan, Li Yan, Ma Guanghui, Su Zhiguo*. ? Determination of leakage from antibody adsorbent: composition analysis ? and pH effect. Biomed Chromatogr. 2013, 27(9): 1089-1091.
[47]Miao ? Shida, Zhang Songping*, Su Zhiguo, Wang Ping. Synthesis of bio-based ? polyurethanes from epoxidized soybean oil and isopropanolamine. Journal ? of Applied Polymer Science. 2013, 127(3): 1929-1936.?
[48]李修乐,刘琳,高建萍,张竞,孔英俊,王明林,张贵锋,苏志国,PEG 化rhG-CSF 的修饰位点识别研究,药物生物技术,2013, 20(4): 348-352.
[49]刘祥玉,张贵锋,张羽飞,王 平,苏志国,马光辉,张松平.化学-酶催化法合成基于鱼鳞胶原蛋白的脂肽类表面活性剂及其在提高原油采收率中的应用. 过程工程学报. 2013, 13(4): 654-661.
[50]姬晓元,王 平,苏志国,马光辉,张松平.中空聚氨酯纳米纤维的制备与表征及其原位固定化酶的应用. 过程工程学报. 2013, 13(3): 481-487.?
[51]樊亚超,张松平,马光辉,周炜清,苏志国,张羽飞. 聚苯乙烯微球吸附脂肪酶催化油酸环氧化的研究。离子交换与吸附, 2013, 29(3): 200-210.
[52]刘祥玉,张贵锋,张羽飞,王 平,苏志国,马光辉,张松平.化学-酶催化法合成基于鱼鳞胶原蛋白的脂肽类表面活性剂及其在提高原油采收率中的应用. 过程工程学报. 2013, 13(4): 654-661.
[53]刁文锦,张松平,王平,周炜清,马光辉,苏志国,张羽飞. 超大孔微球固定化木瓜蛋白酶制备酵母抗氧化肽. 化学工程, 2013, 41(11): 1-4.
[54]周月芳,张焱,罗坚,康丽梅,陈毅,石红,孟庆雄,苏志国. 混合抗体的亲和色谱分离策略。色谱. 2013, 31(10): 974-979.
[55]冯翠,赵大伟,张纯,王健,秦培勇,刘永东,苏志国. 一种重组人睫状神经营养因子突变体的分离纯化及结构鉴定. 中国生物工程杂志,2013, 33(10): 21-27.
[56]康跻耀,张宁, 周炜清,孙李靖,张贵锋,马光辉,苏志国. 基于魔芋葡甘聚糖微球的胶原覆层型微载体的制备研究. 中国生物工程杂志,2013, 5(33): 44-49.
[57]张宁, 康跻耀, 高建萍, 王海燕, 孔英俊, 张贵锋, 苏志国. 胶原蛋白肽分子量对吸收过程的影响研究. 生物学杂志, 2013, 30(2): 10-13.
[58]刘琳, 李修乐, 高建萍, 孔英俊, 王明林, 张贵锋, 苏志国. 燕窝酶解产物中多肽的液相色谱质谱分析. 中国中药杂志 ,2013, 38(5): 714-719.
[59]李笑尘, 闫利华, 王智民, 张启伟, 高建萍, 陈两绵, 王锦玉, 仝燕, 张贵锋. 阿胶酶解物抗氧化肽的分离与质谱分析. 中国中药杂志,2013, 38(7): 18-22.
[60]王晓君, 刘新利, 李秀男, 马光辉, 苏志国. 低场核磁法测定凝胶过滤介质的孔径分布. 化工学报,2013, 64(11): 4090-95.
[61]Wang ? Peng, Wang Yunshan, Liu Yongdong, Shi Hong, Su Zhiguo, Novel in situ ? product removal technique for simultaneous production of propionic acid ? and vitamin B12 by expanded bed adsorption bioreactor. Bioresource ? Technology, 2012, 104: 652-659. (IF 5.352)
[62]Peng Fei, Wang ? Yinjue, Sun lijing, Liu Yongdong, Hu Tao, Zhang Guifeng, Ma Gaunghui, Su ? Zhiguo. PEGylation of Proteins in Organic Solution: A Case Study for ? Interferon beta-1b. Bioconjugate Chemistry. Bioconjugate Chem. 2012, 23: ? 1812?1820.(IF5.224)
[63]Wang Ziqiang, Wang Yunshan, Shi Hong, Su ? Zhiguo. Expression and production of recombinant cis-epoxysuccinate ? hydrolase in Escherichia coli under the control of temperature-dependent ? promoter. Journal Biotechnology, 2012, 162: 232-236. (IF 3.288)
[64]Wang ? Peng, Wang Yunshan, Su Zhiguo. Microbial production of propionic acid ? with Propionibacterium freudenreichii using an anion exchanger-based in ? situ product recovery (ISPR) process with direct and indirect contact of ? cells. Applied Biochemistry Biotechnology. 2012, 166: 974-986. (IF ? 1.998)
[65]Wang Peng, Wang Yunshan, Su Zhiguo. Improvement of ? adenosylcobalamin production by metabolic control strategy in ? Propionibacterium freudenreichii. Applied Biochemistry Biotechnology. ? 2012, 167: 62-72. (IF 1.998)
[66]Ding Fei, Li Xiu-Nan, Diao ? Jian-Xiong, Sun Ye, Zhang Li, Sun Ying. Chiral recognition of metalaxyl ? enantiomers by human serum albumin: evidence from molecular modeling and ? photophysical approach. Chirality. 2012, 24(6):471-480. (IF 2.232)
[67]Ding ? Fei, Li Xiu-Nan, Diao Jian-Xiong, Sun Ye, Zhang Li, Ma Lin, Yang ? Xin-Ling, Zhan g Li, Sun Ying. Potential toxicity and affinity of ? triphenylmethane dye malachite green to lysozyme. Ecotoxicology and ? Environmental Safety. 2012, 78: 41-49. (IF 2.617)
[68]Ding Fei, ? Zhang Li, Diao Jian-Xiong, Li Xiu-Nan, Ma Lin, Sun Ying. Human serum ? albumin stability and toxicity of anthraquinone dye alizarin complexone: ? An albumin–dye model. Ecotoxicology and Environmental Safety. 2012, 79: ? 238-246. (IF 2.617)
[69]Fei Ding, Ye Sun, Jian-Xiong Diao, ? Xiu-Nan Li, Xin-Ling Yang, Ying Sun, Li Zhang. Features of the complex ? of food additive hesperidin to hemoglobin. Journal of Photochemistry and ? Photobiology B: Biology, 2012, 106: 53-60. (IF 2.650)
[70]Zhang ? Guishan, Zhang Fan, Ding Gang, Li Jie, Guo Xiaopeng, Zhu Jinxing, Zhou ? Liguang, Cai Shichun, Liu Xiaoli, Luo Yuanming, Zhang Guifeng, Shi ? Wenyuan, Dong Xiuzhu. Acyl homoserine lactone-based quorum sensing in a ? methanogenic archaeon. The ISME Journal. 2012, 7(6):1336-1344. (IF7.375)
[71]Zou ? Shuping, Xie Luping, Liu Yanli, Kaleem Imdad, Zhang Guifeng, Li Chun. ? N-linked glycosylation influences on the catalytic and biochemical ? properties of Penicillium purpurogenum ?-D-glucuronidase. Journal ? Biotechnology, 2012, 157: 399-404. (IF 3.288)
[72]Wang Jun, Wang ? Yinjue, Hu Tao, Li Xiunan, Huang Yongdong, Liu Yongdong, Ma Guanghui, Su ? Zhiguo. An oriented adsorption strategy for efficient solid phase ? PEGylation of recombinant staphylokinase by immobilized metal-ion ? affinity chromatography. Process Biochemistry. 2012, 47: 106–112. (IF ? 3.225)
[73]马洪梅,张贵锋,李春,孔英俊,高飞,胡涛,马光辉,苏志国. 界面上配基种类对BSA吸附行为的影响. 中国生物工程杂志. ?2012, 32(7):53-59.
[74]冯静,黄孟军,张贵锋,孔英俊,高建萍,黄永东,苏志国. 亲和层析介质上蛋白质偶联位点的控制方法. 过程工程学报. ?2012, 12(2): 277-282.
[75]康丽梅,张焱,罗坚,李由,周月芳,余蓉,苏志国. 超大孔离子交换制备色谱分离纯化高活性凝血因子VIII. 色谱. ?2012, 30(6): 618-623.
[76]初歆, 王鹏, 王云山, 苏志国. 玉米秸秆酶解液发酵生产丙酸联产益生菌. 中国饲料. 2012, 8: 27-30.?
[77]Zhidan ? Liu, Jing Liu, Songping Zhang, Xin-Hui Xing, Zhiguo Su. Microbial fuel ? cell based biosensor for in situ monitoring of anaerobic digestion ? process. Bioresource Technology, 2011, 102(22):10221-10229
[78]Jun ? Wang, Tao Hu, Yongdong Liu, Guifeng Zhang, Guanghui Ma, Zhiguo Su. ? Kinetic and stoichiometric analysis of the modification process for ? N-terminal PEGylation of staphylokinase. Analytical Biochemistry, 2011, ? 412: 114-116
[79]Lan Zhao,Yongdong Liu,Yongdong Huang, Xiunan ? Li,Yinjue Wang,Yan Li, Guanghui Ma,Zhiguo Su. Deliberate manipulation of ? the surface hydrophobicity of an adsorbent for an efficient ? purification of a giant molecule with multiple subunits. Journal of ? Separation Science, 2011, 34, 3186-3193
[80]Yingjun Kong, Guifeng ? Zhang, Jian Luo, Yongdong Liu, Xiunan Li, Guanghui Ma, Yalin Zhao, ? Sanping Yuan and Zhiguo Su. Facile purification and characterization of ? recombinant human antithrombin III from transgenic goat milk. J Chem ? Technol Biotechnol, 2011, 86: 1303–1309
[81]Chunyang Zheng, ? Zhanyong Zhao, Yan Li, Lin Wang, Zhiguo Su. Effect of IPTG amount on ? apo- and holo- forms of glycerophosphate oxidase expressed in ? Escherichia coli. Protein Expression and Purification, 2011, ? 75(2):133-137
[82]Tao Liu, Guifeng Zhang, Suping Li, Yinjue Wang, ? Guanghui Ma and Zhiguo Su. Analysis of gelatin plasma substitutes in ? blood based on detection of hydroxyproline derivatives. Artificial ? Cells, Blood Substitutes and Biotechnology, 2011, 39(1): 19-25
[83]Lijing ? Sun, Yongdong Huang, Yan Zhang, Qingqiang Meng, Jian Luo, Bei Fan, ? Guanghui Ma and Zhiguo Su. A Simple and Rapid Procedure for Purification ? of Haptoglobin from Human Plasma Fraction IV. Artificial Cells Blood ? Substitutes and Biotechnology. 2011, 39(2):79-86
[84]李由,张焱,苏海佳,罗坚,白倩,马光辉,苏志国. 乳腺生物反应器表达的重组人乳清白蛋白的快速纯化工艺. 中国生物工程杂志, 2011,31(8): 66-72
[85]孙西艳,张焱,罗坚,李岩,马光辉,苏志国. 乳腺生物反应器表达产物层析分离过程中介质的污染机理及其再生策略. 生物工程学报, 2011, 27(11): 1645-1654
[86]高建萍,刘琳,张贵锋,王明林,黄永东,刘永东,苏志国. 多级逆流固液提取技术提取大豆分离蛋白. 过程工程学报, 2011,11(2):312-317

授权和申请发明专利(近5年)

[1] 张竞,苏志国,刘强,窦婧,马光辉,一种异端基双官能团烷基醚类化合物及其用途,ZL20121014394.5
[2] 张竞,周展,苏志国,马光辉,聚乙二醇修饰的重组人干扰素β-1b及其制备方法,ZL201310066150.8
[3] 李秀男,苏志国,电极清洗、校正和保存装置及方法,ZL201310062061.6
[4] 李秀男,苏志国,一种多参数一体化色谱流通池,ZL201310088098.6
[5] 李秀男,苏志国,一种多功能的通用阀,ZL201310062077.7
[6] 李秀男,沈志刚,苏志国,崔万臣,生物技术药物高效纯化分析系统及其药物分离检测方法,ZL201310198644.1
[7] 李秀男,沈志刚,苏志国,崔万臣,陈超,一种车载便携式液相色谱仪,ZL201310701298.4
[8] 李秀男,沈志刚,苏志国,崔万臣,陈超,一种荧光和紫外可见吸收一体化流通池,ZL201310701299.9
[9] 张松平,苏志国,刘祥玉,张羽飞,张贵锋,王平,一种生物表面活性剂及其制备方法,ZL201310286865.4?
[10] 张竞,苏志国,刘强,窦静,马光辉. 白蛋白-聚乙二醇-药物分子偶联物. 中国发明专利,专利号:ZL201210183104.1
[11] 张松平,苏志国,姬晓元,王平. 一种中空聚合物纳米纤维的制备方法. 中国发明专利,专利号:ZL2012102175
[12] 李秀男,苏志国. 蛋白层析系统. 中国发明专利,专利号:ZL201010127899.5
[13] 张焱,苏志国,罗坚,马光辉. 一种从乳腺生物反应器表达产物中分离重组人抗体的方法. 中国发明专利,专利号:ZL201110240519.3
[14] 张焱,苏志国,罗坚,马光辉,康丽梅. 一种分离纯化凝血因子VIII的方法. 中国发明专利,专利号:ZL201210022202.7
[15] 苏志国,张贵锋,刘永东,余蓉,谢伟全. 一种抗凝溶栓双功能融合蛋白的亲和层析复性方法. 中国发明专利,专利号:ZL201010279445.X
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[20] 苏志国,马光辉,王俊,刘永东,胡涛. 聚乙二醇-葡激酶偶联物及其制备方法和应用.?
[21] 张羽飞,张松平,苏志国,李鹏举. 一种界面靶向膜和界面靶向纤维的制备方法. ZL201210032999.9.
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[24] 苏志国,马光辉,雷建都,李兴奇,郑春杨,翟艳琴. 支链聚乙二醇-干扰素结合物及其制备方法. ZL200610011207.4.
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